Tramadol 100mg

Description

Pharmacology of Tramadol 100mg

Tramadol is a centrally acting synthetic analgesic compound. It works by inhibiting the reuptake of neurotransmitters such as serotonin and noradrenaline. This modulation alters pain signal transmission by activating both descending serotonergic and noradrenergic pathways. The analgesic effects of Tramadol are achieved through stimulation of mu-opioid receptors and indirect modulation of central monoaminergic inhibitory pathways.

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Tramadol Dosage & Administration Guidelines

Capsule or Tablet – Buy Tramadol Online 50mg to 100mg

The usual dosage ranges from 50 to 100 mg every four to six hours. For acute pain, an initial dose of 100 mg is recommended. For chronic conditions, begin with 50 mg. Subsequent doses should be taken every 4–6 hours depending on the severity of pain. The maximum oral dose should not exceed 400 mg per day.

Tramadol Sustained Release (SR) Capsule or Tablet 100mg

Take one sustained-release capsule or tablet every 12 hours — typically once in the morning and once in the evening. The number of capsules may vary based on pain intensity but should not be taken more frequently than every 12 hours. Total daily oral dosage must not exceed 400 mg.

Tramadol Injection Dosage (IM/IV Use)

Administer 50–100 mg every 4 to 6 hours via intramuscular or intravenous infusion. For postoperative pain, begin with 100 mg, followed by 50 mg every 10–20 minutes as needed, not exceeding 250 mg in the first hour. Then continue with 50–100 mg every 4–6 hours. Maximum daily dose: 600 mg.

Tramadol Suppository 100mg

Administer rectally. The standard adult dose is 100 mg every 6 hours. A total of 400 mg per day is usually sufficient (4 suppositories). Higher doses may be necessary for cancer or post-operative pain.

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Drug Interactions with Tramadol

Tramadol generally has a low risk of drug interactions. However, it should not be taken with monoamine oxidase inhibitors (MAOIs). Concurrent use of carbamazepine increases Tramadol metabolism, which may require dose adjustments.

Danger of Taking Medication Without Doctor’s Advice

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Tramadol Contraindications

Tramadol is contraindicated in individuals with known hypersensitivity to the drug. It should also not be used in cases of acute alcohol poisoning, or in combination with hypnotics, centrally acting analgesics, opioids, or psychotropic medications.

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Common and Rare Tramadol Side Effects

Common side effects: dizziness, nausea, vomiting, constipation, headache, drowsiness, itching, dry mouth, and sweating.

Less common side effects: malaise, allergic reactions, weight loss, palpitations, GI bleeding, hepatitis, flatulence, and stomatitis.

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Tramadol Use During Pregnancy and Breastfeeding

The safety of Tramadol in pregnant women has not been well-established. Tramadol crosses the placenta, and there are no adequate, controlled studies in pregnant women. Use only if clearly needed. Tramadol and its metabolites are excreted in breast milk; therefore, avoid use while breastfeeding.

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Precautions & Warnings for Tramadol 100mg

• Respiratory Depression: Use caution if combined with anesthetics or alcohol.

• Opioid Dependence: Tramadol is not suitable for opioid-dependent individuals.

• CNS Depressants: Reduce dosage when used alongside alcohol, opioids, sedatives, or tranquilizers.

• MAO Inhibitors: Extreme caution required due to overlapping effects on neurotransmitter reuptake.

• Neurological Concerns: Exercise caution in cases of head injury, increased intracranial pressure, or acute abdominal conditions.

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Tramadol Use in Children and Special Populations

Children over 1 year can be given 1–2 mg/kg body weight of Tramadol. Suppositories (100 mg) are not advised for children under 14 years. Sustained-release capsules have not been adequately studied in children, and should therefore not be used.

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Therapeutic Class of Tramadol

Opioid Analgesics.

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Storage Conditions for Tramadol Tablets and Injections

Store below 30°C in a dry place, away from light and moisture. Keep out of the reach of children.